MetalHead

my last trauma unit visit it was initially propofol and ketamine. after 2 rounds of IV morphine in the flash box. what's funny is I told the EMTs I was good and didn't need the morphine. then one of them said "we'll you're definitely going to want it later" so I told him to load me up. don't remember much after that except coming out of emergency surgery after the propofol and ketamine. and when they asked how I was feeling I said "that was wonderful". I didn't take any of the painkillers after they discharged me 36hrs later. as soon as I got home I took probably the best poop of my life.
 
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Okay call me old but wtf is ketamine? I thought it was a rhinoceros tranquilizer or some crazy shit but I heard it in some videos and one kick ass song so I have to ask.
Yeah, I could look it up on the algores but I’d rather hear the bbs version.
 
Dave K said:
Okay call me old but wtf is ketamine? I thought it was a rhinoceros tranquilizer or some crazy shit but I heard it in some videos and one kick ass song so I have to ask.
Yeah, I could look it up on the algores but I’d rather hear the bbs version.
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Think back to Michael Jackson, my shortness.
 
Dave K said:
Okay call me old but wtf is ketamine? I thought it was a rhinoceros tranquilizer or some crazy shit but I heard it in some videos and one kick ass song so I have to ask.
Yeah, I could look it up on the algores but I’d rather hear the bbs version.
Click to expand...

It’s apparently what the girls you don’t need to roofie use to prepare themselves for a trip on a train…
 
Once a Wanker.. said:
Think back to Michael Jackson, my shortness.
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Michael Jackson died from propofol. It is only approved to be given in a hospital setting. MJ’s private doctor gave it to him in his bedroom and then walked out into the hallway and called his girlfriend on his cell and talked for 12 minutes. That’s why the doctor ended up in jail. Propofol is an amazing drug, but it must be carefully administered and you must monitor the patient continuously.
 
Ketamine… special K used to come from vet clinics as a cat tranquilizer and they’d dehydrate it and snort it… an industrial/goth chick I met at DePaul around 1992 in Chicago and then entertained in Columbus used to live in a house where someone worked for a vet… and one at a hospital… so nitrous bottles… the underground industrial rock scene in OH of all places was really good… I mean NIN started in Cleveland… odd party favors for that hardline music though… not like it was Phish

I’ve never done it but ketamine is all over as the new thing for depression and clinics all over… NZ just opened up MDMA treatment…


There was a good xfiles episode when Moulder gets thrown into a Khole and navigated his way out…. Billy Strings said they used it on him when he broke his leg skateboarding and described it… if they’ve ever used it as anesthesia on me I don’t remember any of it…
 
StanTheMan said:
Michael Jackson died from propofol. It is only approved to be given in a hospital setting. MJ’s private doctor gave it to him in his bedroom and then walked out into the hallway and called his girlfriend on his cell and talked for 12 minutes. That’s why the doctor ended up in jail. Propofol is an amazing drug, but it must be carefully administered and you must monitor the patient continuously.
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Stan,
For my last three surgeries all in the last year what’re they using to put me out via the breathing mask? They said for the last one they didn’t have to use the breathing tube as they weren’t putting me that deep under… surgery lasted an hour though…

All my surgeries before these I remember the IV getting warm and going out… these I was watching my iv port when I went out and they weren’t using it…

Hope you’re well my man… thanks again for helping everyone you can brother…
 
27 said:
Speaking of Speedy…. How’s he doing anyone know? I remember his health was better..
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He messaged me recently on Facebook when I posted about the contraption I have to use for my lymphedema. He seems to be doing well
 
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Over the past 50 years, the use of ketamine for anesthesia has become widespread in both human and veterinary medicine. Its safety and short duration and unique mode of action have made ketamine an important drug in emergency medicine and pain management around the world. The study and use of ketamine for the treatment of several new indications, ranging from pain syndromes to drug addiction and psychiatric disorders, is constantly growing. In experimental research, ketamine has unarguably contributed to a better understanding of the glutamatergic system and the development of animal models of schizophrenia [1].

Perhaps the greatest contribution to the legacy of ketamine has been the discovery of its rapid-acting antidepressant effects [2], which has effectively revitalized interest in the development of new antidepressant drugs with a novel mode of action. Indeed, the past decade has seen a rapid increase in the number of research papers associated with ketamine’s antidepressant effects [3]. It can be argued that even beyond its important role in anesthesia, ketamine is a top contender for being the drug with the largest impact for research and treatment of psychiatric disorders in the past several decades.

The ability of ketamine to provide a rapid relief of depressive symptoms, often within hours, has brought it to the forefront of treating severe treatment-resistant depression [4]. Despite its relatively fast pharmacokinetics, the antidepressant effects of ketamine are sustained for up to 1–2 weeks [5]. This rapid onset of ketamine’s action combined with a sustained response lasting far beyond its acute pharmacological effects has puzzled researchers and medical doctors. In contrast, typical antidepressant drugs, such as selective serotonin reuptake inhibitors, often require weeks or even months of continuous medication to elicit their beneficial effects [6]. While the last 2 decades of basic and clinical research have significantly contributed to the understanding of ketamine’s complex profile of effects and its potential for the treatment of psychiatric disorders, the precise neurobiological basis of its antidepressant action remains unclear.

With a vast amount of research aimed at untangling the mysteries of its action, an ever-increasing number of molecular targets and mechanisms have been associated with the antidepressant effects of ketamine [7]. A myriad of novel drug candidates, essentially mimicking certain aspects of ketamine’s action, have risen out of preclinical research. However, to date, no new drug has conformed to the high expectations, with multiple candidates failing in recent clinical trials [8–10]. The shortcomings of animal models of depression are often discussed as a plausible explanation for these failures of translational research, but many other aspects also require further examination. In the rush to understand the molecular complexities of ketamine’s action, both basic and clinical researches have overlooked details related to the administration and dosing time of ketamine [11, 12]. For example, studies directly comparing different dosing parameters and pharmacokinetics between human and rodent studies are still lacking.

With many new ketamine studies published each year, staying up to date becomes a challenge. Thus, the purpose of this review is both to introduce the reader to the various uses of ketamine from anesthesia to pain management and psychiatric use and to provide a thorough overview of the current understanding of ketamine’s effects in treating depression. Herein, the multifaceted profile of ketamine’s effects is reviewed, and studies addressing molecular, cellular, and network mechanisms are introduced. A special emphasis is placed on discussing issues associated with the dosing of ketamine in both basic and clinical research as well as on discussing some of the latest hypotheses related to ketamine’s antidepressant mechanisms.
 
John Branch said:
Over the past 50 years, the use of ketamine for anesthesia has become widespread in both human and veterinary medicine. Its safety and short duration and unique mode of action have made ketamine an important drug in emergency medicine and pain management around the world. The study and use of ketamine for the treatment of several new indications, ranging from pain syndromes to drug addiction and psychiatric disorders, is constantly growing. In experimental research, ketamine has unarguably contributed to a better understanding of the glutamatergic system and the development of animal models of schizophrenia [1].

Perhaps the greatest contribution to the legacy of ketamine has been the discovery of its rapid-acting antidepressant effects [2], which has effectively revitalized interest in the development of new antidepressant drugs with a novel mode of action. Indeed, the past decade has seen a rapid increase in the number of research papers associated with ketamine’s antidepressant effects [3]. It can be argued that even beyond its important role in anesthesia, ketamine is a top contender for being the drug with the largest impact for research and treatment of psychiatric disorders in the past several decades.

The ability of ketamine to provide a rapid relief of depressive symptoms, often within hours, has brought it to the forefront of treating severe treatment-resistant depression [4]. Despite its relatively fast pharmacokinetics, the antidepressant effects of ketamine are sustained for up to 1–2 weeks [5]. This rapid onset of ketamine’s action combined with a sustained response lasting far beyond its acute pharmacological effects has puzzled researchers and medical doctors. In contrast, typical antidepressant drugs, such as selective serotonin reuptake inhibitors, often require weeks or even months of continuous medication to elicit their beneficial effects [6]. While the last 2 decades of basic and clinical research have significantly contributed to the understanding of ketamine’s complex profile of effects and its potential for the treatment of psychiatric disorders, the precise neurobiological basis of its antidepressant action remains unclear.

With a vast amount of research aimed at untangling the mysteries of its action, an ever-increasing number of molecular targets and mechanisms have been associated with the antidepressant effects of ketamine [7]. A myriad of novel drug candidates, essentially mimicking certain aspects of ketamine’s action, have risen out of preclinical research. However, to date, no new drug has conformed to the high expectations, with multiple candidates failing in recent clinical trials [8–10]. The shortcomings of animal models of depression are often discussed as a plausible explanation for these failures of translational research, but many other aspects also require further examination. In the rush to understand the molecular complexities of ketamine’s action, both basic and clinical researches have overlooked details related to the administration and dosing time of ketamine [11, 12]. For example, studies directly comparing different dosing parameters and pharmacokinetics between human and rodent studies are still lacking.

With many new ketamine studies published each year, staying up to date becomes a challenge. Thus, the purpose of this review is both to introduce the reader to the various uses of ketamine from anesthesia to pain management and psychiatric use and to provide a thorough overview of the current understanding of ketamine’s effects in treating depression. Herein, the multifaceted profile of ketamine’s effects is reviewed, and studies addressing molecular, cellular, and network mechanisms are introduced. A special emphasis is placed on discussing issues associated with the dosing of ketamine in both basic and clinical research as well as on discussing some of the latest hypotheses related to ketamine’s antidepressant mechanisms.
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Years ago I would have been impressed by the knowledge that this post seems to contain. Now I read it and just somehow know that this was likely created by AI.
 
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Pharmacol Rep
. 2021 Feb 20;73(2):323–345. doi: 10.1007/s43440-021-00232-4

Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms​

Samuel Kohtala 1,2,3,✉
  • Author information
  • Article notes
  • Copyright and License information

PMCID: PMC7994242 PMID: 33609274
Over the past 50 years, ketamine has solidified its position in both human and veterinary medicine as an important anesthetic with many uses. More recently, ketamine has been studied and used for several new indications, ranging from chronic pain to drug addiction and post-traumatic stress disorder. The discovery of the rapid-acting antidepressant effects of ketamine has resulted in a surge of interest towards understanding the precise mechanisms driving its effects. Indeed, ketamine may have had the largest impact for advancements in the research and treatment of psychiatric disorders in the past few decades. While intense research efforts have been aimed towards uncovering the molecular targets underlying ketamine’s effects in treating depression, the underlying neurobiological mechanisms remain elusive. These efforts are made more difficult by ketamine’s complex dose-dependent effects on molecular mechanisms, multiple pharmacologically active metabolites, and a mechanism of action associated with the facilitation of synaptic plasticity. This review aims to provide a brief overview of the different uses of ketamine, with an emphasis on examining ketamine’s rapid antidepressant effects spanning molecular, cellular, and network levels. Another focus of the review is to offer a perspective on studies related to the different doses of ketamine used in antidepressant research. Finally, the review discusses some of the latest hypotheses concerning ketamine’s action.

Keywords: Ketamine, Subanesthetic, Rapid-acting antidepressant, Depression, Dose, Anesthesia

This is where I got it from, should have copied all. It could be AI ? Like everything in life you take with a grain of salt.
 
Dave K said:
I didn’t know what killed him. Shooting smack with Gobert, smoking crack with Oprah or if bubbles ripped his face off and ate it. Never really thought about it but something as totally f’ed up as Propofol makes sense.
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I posted something for you in the youtubes earlier.
 
Fair enough. My main point was that there was a time where some members here could post something very informative based entirely on their own education, knowledge and experiences. Those days are obviously gone now. This wasn't an attack on you...
 
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